Gendustry removes a lot of the guessing and the tedious aspects from bee breeding. You still need at least some infrastructure first, because it takes quite a few diamonds when you get into the genetics and RF to run the Industrial Apiaries.
But aside of that it is really straightforward. Look up what species you need and what bees are required. Put them into an (Advanced) Mutatron and you get a queen of that species. No worrying about mutation chances or restrictions to breed the species, it's really very convenient.
Some knowledge doesn't hurt though. What genes to extract to produce the "perfect" bee, how to use normal apiaries with Oblivion frames together with Gendustry to speed up the process, when and how to use the Genetic Imprinter. But all that comes also after you got started already.
Or watch a couple YouTube videos. As with everything AgSkies related, PurpleMentat would be my first recommendation here.
I wouldn't use vanilla Forestry machines for bee breeding at all, especially if the player has not had much experience with Forestry prior.
???? Sorry, this is wayyyy over my head. I literally know almost nthing about bees and trees. Is there a easy yo understand guide out there?
Extract a shortest life sample with a Genetic Sampler as soon as possible. I believe Cultivated bees have this.
Extract a 2, 3, or 4x fertility as soon as possible.
Extract a Fast or Fastest Production.
Extract a None effect.
Designate at least one Industrial Apiary for bee breeding- I had 6 just for breeding. Put in 4 life upgrades. If you haven't quite gotten temperature and humidity tolerance, you might need a slot or two for those upgrades to get the environment right for the particular bee you're breeding. The fourth slot could be used for production upgrades, light upgrade, seal, or whatever else you need.
The life upgrades- contrary to their names- actually decrease the lifespan of a bee. With 4 of those and a shortest lifespan, you'll be cycling bees in no time. I recommend stocking up on a handful of drones and definitely waiting for more princesses to spawn in case you need them for crossbreeding later.
You can stack industrial apiaries on top of each other. Put a light upgrade in the top one and depending on how high you've stacked them, it will provide light for those below. I stacked mine 3 high.
I never had a use for standard apiaries or even alvearies. The time wasted setting up frame production/insertion and the space taken up by alvearies just isn't worth it if you've got the resources and power for industrial apiaries.
My final genetic template for bees is as follows:
Fertility: 4x
Production: Fastest
Lifespan: Shortest (or Longest if you don't need to rapidly breed)
Pollination: Fastest
Area: Normal/Average
Humidity Tolerance: Up/Down 3
Temperature Tolerance: Up/Down 3
Flowers: Flowers
Ignores Day/Night: True
Tolerant Flyers: True
Cave Dwelling: True
Effect: None
With this template, you can finish bees very quickly. If you use the Advanced Mutatron to get a queen of your desired species, cycle it once then feed the princess and one drone back through the Imprinter. Breeding these two together will result in a stable species with the traits from your template.