Depends on how you approach it. Self sacrificing is very grindy and boring. But maybe with the Botania regenerating flower nearby you can make it faster.
Now, if you set up a fast producing mob farm (or villager farm; I won't judge) you can make it much faster and automatic with the ritual of th feathered knife.
I say "fast producing" at least for the third(if I'm not mistaken) orb, where you need mor blood than your altar can hold. Unless you have some runes upgrading the capacity.
But once/if you set a form of automated farming, you'll end up with more blood than you can use.
(I am, obviously, not considering the ritual to summon the demon invasion to get the last orb, as it will drain your pool completely)
Edit: forgot to mention that the transmutations involving the altar can make it even more boring.
Unless you automate it. Not sure how/if you can do it in this pack. But from my experience on techy packs, you will have minimal blood loss with automatic systems, as the output is only sucked out once it is recognized as being an output.
For example, a slate will start transmutating into a superior tier almost instantly oif it is not manually pulled out. However, if you are using an automated blood farm this is irrelephant.
