My system on my old world (unfortunately the computer that is on is currently sat in a corner smoking after it mildly blew up and is awaiting new parts) used around 800 AE units and was pretty much hooked up to everything in a 5 tall 21*21 monolith I had built. It was keeping coke ovens stocked storing everything from a giant tunnel bore as well as having auto crafting. I also found that it works pretty well for forestry machines such as the fermenter and will put the sapling and fertilizer in the correct slots no problem.
I normally keep things that I would need to fix a system like that in barrels with storage busses connected in a different building to my main stuff. So I can still acess the stuff from an ME terminal thanks to the storage busses but if the system goes offline for whatever reason then I can still manually access the stuff by just going to the barrels.
How in the hell did you blow up a computer