I like everything about it except the Macerator recipe, which I disabled thanks to the config. Even metal-block crafting requiring the compressor and mixed ingots requiring a rolling machine I think is pretty awesome.
The centrifuge is one of those fire-and-forget machines, which isn't a problem for me. I just shove some stuff in and go mining for awhile or setting up some other machines. It's not a machine where you make items on demand, which everyone wants it to be. I've been throwing tons of extra resources and dusts into the centrifuge to create a reserve of these centrifuged materials because I know I'm going to need them for mid-late game.
The recipe changes, save the Macerator, I believe are fair and favorable. A drill that mines as fast as Eff III diamond pick and never breaks? A chainsaw that's as powerful as a Sharpness IV diamond sword, acts like shears, and obliterates trees? I think having to go to the Nether and find a stronghold for such luxuries is perfectly reasonable.