After reading up on the math on how ME Storage drives from Applied Energistics determines byte size per item I was wondering is there any point in using larger disks since with larger disks items take up exponentially more bytes. (i.e. 1k storage drive 8 bytes= 1 item; 64k storage drive 512 bytes = 1 item)
Here is a link to the AE Storage Math where I found the information: http://ae-mod.info/ME-Storage-Math/
For general storage, smaller cards will do the job. However, 64k are excellent for storing items you'll get vast amounts of, such as Cobblestone or Sand (if you're digging in a desert). A pre-formatted 64k card can hold several hundred thousand Cobblestone, more than enough to take in whatever your Quarries spit out.