You stay at home, but you have a sick sibling who also must stay at home. The sibling then passes on the disease to you, and you have to spend 6 months in a hospital, only living due to life support machines.
Granted. It mutates into a giant enemy tree that spawns Superwisps (wisps with 500 health and that deal 20 damage a hit, and can hit you from 25 blocks away), as well as pouring massive amounts of flux into the environment.
She is even stunning, smart, obsessed with you and will never leave your side.
Unfortunately she hates you with such passion that she intentionally spends all your money, gets you in debt, sleeps with everyone -except you- including people of such hideousness you consider she is a circus trawler, wakes you in the middle of the night with a punch to the face, urinates inside your computer -yes even removing coverings beforehand- and spreads malicious rumours about your "substandard equipment", "poor performance", "bedroom habits which are so past freaky that manson would look at you with horror", and also various diseases.
I wish I could jump back time by 24 hours at will, and that the travel was easy, did not disturb reality or harm anyone, could be repeated at any time by me alone, was interlinked with gravity to make sure I travelled to the same spot I was standing on (so I wouldn't just be left in space when earth moved backwards a day)..... And it tickled briefly.
BlaskFire: "I wish I had an Arby's near me." Genie: "Your wish is my command master!" After a year you die of a heart-attack from eating Arby's too much. (try this wish again) I wish I could end world hunger without anyone dying.