I'm sure it's possible to play any HQM pack without using the questbook, I think that the quests are part of the experience. Having a well-constructed progression of quests helps a newcomer to a particular mod get more comfortable using it.
That said, I have had to go 'off the rails' once or twice. It's nearly(?) impossible to get a creeper heart without an arthama, and the existence of that is only hinted at in the Chalice/Candelabra quest.
I just gave up after I broke my second enchanted arthana (killing only creepers) and followed the quests - there are at least two Witchery quests (if I am not mistaken) which reward creeper hearts. Used the first one for the seeds because infinite hearts from there on.