I'm not an expert, these are just some things that I've found useful.
In random order...
1/ Save your Epic & Legendary reward bags till you have enough to make the infused seeds. (5 for epic, 10 for legendary). If you've got the seeds, make more seeds.
You can automate them a litle bit: place 3x3 farm with autonomous activators around them and a vacuum hopper in the middle. Use AA to place and another AA with crystal hammer to break. Use a vacuum chest to pick up the rough shards. Use item conduits to import rough shards into a gem cutter. I didnt quite get them to automatically put them in the refiner so i've done this manually.
Even without the cutter & refiner, you get random bags directly from the seeds occasionally.
Put a torcherino in the middle block of your 3x3 farm and set it to 400% speed (right click or shift right click w empty hand). I get hundreds of legendary bags in less than an hour and I dont even bother with the chunks anymore. You can expand the farm but w a torcherino, its not even worth it.
Once you've gotten this done, all ages are easy. You get Fairy Wings and great armor & weapons. Ive played through the ^4 versions since biosphere without dying once. This map pack actually gets easier once you progress.
2/ Farm Greater bags in hopes of getting world interaction upgrades. They make _excellent_ cobble gens. There are bags w 5 or 6 stacks of WIU. If you're lucky enough to get some, you get octuple compressed in a matter of hours.
3/ Start MineChem early on and learn to use the Fission and Fusion reactors in the Chem Lab. You can get rare resources easily by dividing or adding the right atomic number. Use the real table of elements. Google it. MineChem btw, is AWESOME.
4/ If you have your first torcherino, the sugar cane quest is easiest. I've set up 4x4 annihilation planes, importing into 2 64k drives in an ME drive connected to a ME controller. Use a dense energy cell to power it or just connect to your main power network using an energy acceptor. Took me a couple of hours but you get 2 torcherino's from it.
5/ Torcherino is not as hard as it looks. I've managed to get one by the time I unlocked Biosphere^4. Perhaps it can be done sooner but I was a noob in the beginning.
The hardest part is the octuple compressed cobble.
6/ EXPLORE THE USER AGES!! I can't stress this enough. There are HUGE amounts of resources. In one of them, there's like 16 ME drives with a bunch of storage cells. Don't bother making them.
7/ Enchant your armor if you dont have acces to legendary bags yet. DW20 has talked about this but never done so, its absolutely worth it. Use the Ender IO enchantment things. Also, start storing your XP in tanks & drain early on. Don't lose it while dieing.
8/ You can "cheat" by quarrying out the spatial IO area's. Ive done this with the SAND age. But move your spatial input area before you start doing this. Bad things will happen if you dont. You can also quarry out the other ages but that kinda ruins itt.
9/ In orde to get the dirt seed, which was one of the hardest ones for me, believe it or not!, ive used a quarry without a world hole upgrade to replace all blocks w dirt. The i requarried the area w the world hole upgrade and got enough dirt to make the seed.
10/ Explore ALL the area's. Melons! And look below...
11/ Use a rapier and level it up! This will make killing the carmite (carmonite?) zombies a lot easier and the knockback effect doesnt count when using a rapier. Also put beheading and looting III on it. Once you get to Rotunda^4, just spawn a bunch of zombies, let them chase u, punch out an ethereal glass and stab them w your rapier. They'll drop lots of their awesome armor, you'll level up your rapier like you wouldnt believe. This is usefull if you havent gotten the legendary bags thing under tip 1 done yet.
12/ Make a bow early on! Spend time leveling it up. Once you can oneshot mobs, things will get a lot easier.
13/ Necessary items for exploring: 64 Cobble, 64 gravel (or sand). Dont bother killing all the mobs, focus on the spawners instead. Tunnel above them, near the ceiling where arrows wont hit you, using cobble. Use gravel to drop around the spawners, go down, break spawner, repeat, kill remaining mobs. Ive used lava buckets and orbs, but pyrotheum is better.
14/ Make a pump, tank and energy cell (you should have plenty from bags). Make drums. Import all liquids in the huge tanks into drums. They'll be useful later on.
15/ Fill your reactor w gelid cryotheum.
16/ Exploring is a walk in the park if youve got angel wings. By that time, you'll have awesome armor. The sanginuite armor works really well but I prefer the dark plating set. Just make sure you repair it in time.
17/ In order to kill enderman early on: use broken spawner, combine w ender io spawner, set it to capture and put soul vial in, use your ender io sword (they wont teleport that way).
18/ Use the exchanger to find forgotten trophies. The bags arent really worth it anymore by the time youll be able to make the exchanger.
19/ Make a builders wand! This is ofcourse very usefull for expanding your area. You wont fall down as easily. And its also usefull when exploring.
20/ Take your time setting up your infrastructure before you go explore the spatial io area's. Automate as much as possible. Its always nice coming back from an exploring trip seeing you've gathered a lot of resources because you've set up a good automating structure.
Just my 2 cents