To supply a reactor with fuel you need uranium. You can process uranium in several ways.
If you macerate it to dust and centrifuge it: for 16 uranium dust you get just 16 uranium cells, 1 plutonium, and 4 thorium.
vs
If you compress it you get a uranium ingot.
You have two choices of what to do with that ingot:
Pair it with one empty cells to get a uranium cell --might have to use canning thing if gregtech.
If instead of one cell you craft the ingot with 8 empty cells it will make 8 near depleted uranium cells.
To process depleted cells you have 2 choices. Centrifuge 2 of them for 1 thorium or recharge them to enriched cells using a breeder reactor.
To breed cells, add coal dust to a near depleted cells to get a depleted isotope -- these go in a reactor and make no power, but build up a charge. Put the isotope next to a single fuel cell in a reactor for 10,000 reactor ticks (1 tick per second) and it will convert to a re-enriched isotope. For every 3k heat the reactor has the charge will be multiplied, so it pays to run a breeder with at least some heat. Dual and quad cells supply multiple charges per tick, so 1 quad cell would give 4 charges per tick (quad thorium is very good for this).
With your re-enriched isotope you again have choices:
Add coal to that to get a full uranium cell
vs
centrifuge 8 of them for 4 thorium, 1 plutonium, and 3 near depleted cells
With that the most fuel efficient path is to compress your uranium, then make it into 8x near depleted cells, add coal - enrich isotopes in a breeder, centrifuge -- run the thorium and plutonium in your power reactors and any depleted cells from the reactors or recycled and recharged.
The reactors you posted are actually designed to be run in a group. I believe it is for each 484 EU/t design run two 420 EU/t. Centrifuging their fuel out the 420s will need an extra 4 thorium each cycle, while the 484 will need extra plutonium. So you end up keeping your thorium and plutonium use in balance -- making the most of your fuel.
Here is a little 367 EU/t gregtech breeder i have been working on in the IC2 reactor thread:
http://www.talonfiremage.pwp.blueyo...4qbzfj7njhh1swr8v5nzsm9upgcbzzc239mx3b3o7pvr4
It runs in balance and can recharge enough cells to run the 400 EU/t reactors.
One thing to learn about heat in the reactor is it is not bad if you design it to run hot. Their is no more risk than in a cold reactor -- if someone (or a creeper) removes a critical component in either reactor they will both blow up. In the current version reactors run the edge so losing even one vent will make one blow fairly quick.