ok, while I will say there is a debatable best set up for molecular assemblers/interfaces, there's not "best way" to set up the crafting units/co-processors. also, where are you getting this "depth and intrigue" if I want to automate smelting in AE2, I place an interface with the processing pattern to make it onto the smelter, and in RS all I have to do is place that smelter in front of a crafter instead with the pattern for what I want. the only difference is that in AE2 I have to make sure my system has the channel available, which is easily done by placing a new controller on the cable, or just porting from a different side of a controller. and other than that I can just slap a couple crafting units and co-processors somewhere where i'm not using a lot of channels and we're good to go. the only real differences between the two systems is that RS cuts the middle man and doesn't need a block to make basic recipes. saying that AE2 is more "in-depth" and "intrigue" is like saying that "my plug is better than your wireless charger because I have to open the power input on my phone and insert the wire" it really just doesn't hold up when you look at the big picture
Also, I feel I should bring up that auto-crafting, at least with the sense that AE2 does it, isn't as OP as everyone thinks. I could easily run a few calculations through a calculator to figure out what I need, make the materials, and craft it all by hand. would it be tedious and probably make me leave the game and not come back because I don't want to deal with it? maybe, but is it doable? a sure fire yes