I'm of mixed emotions about the massive changes to AE2, but mostly positive.
On the one hand, the old MAC really was incredibly powerful for auto-crafting, easily pwning any other autocrafting system that has ever come out. And AE in general was cheap enough that the solution to any automation question was 'hook it up to the ME Network, that way you get all the stuff and get to automate it at the same time, because why not'.
I mean, look at DW20's base. He's using P2P tunnels to pipe WATER all over the place. P2P tunnels... just to move around water. Because it was cheaper.
Other than the whole plates appearing only as chest loot in random meteorites and a compass that doesn't work very well, what happened was a whole new level of complexity, however it wasn't simply 'do a bazillion sub-combines and stare at your crafting grid for two hours' like IC2 EX decided to do.
Channel Management has become an exciting challenge. Then again, I was the crazy guy who came up with CRCS and Tower of Power builds, so I guess I'm used to it by now. P2P tunnels are now useful as more than just moving water around, you can move channels too. Send 32 channels through a P2P tunnel. You'll now actually see a use in coloring ME Cable, covered cable, and smart cable. Sub-Networks are now a Thing.
Previously, when you had a sub-system that would output a finished product, you just hooked it up to the main system. In AE2, you can't quite do that, BUT you can pipe stuff out of your dedicated sub-system to any ME Interface in your main system and still have access to the product without eating up the channels from your sub-system. Also, there's plenty of ways that don't involve using buses to automate stuff. Many machines now will auto-eject, meaning you only need an ME Interface, not a bus, and that one ME Interface can accept piped input as well, meaning you only need a single Interface for all of the outputs on the entire system. That alone can dramatically reduce the number of channels you use. There's just... I'm going to have to write a whole guide dedicated to channel management.