There is one serious deficiency in Digital Chests compared to Barrels:
Digital/Quantum Chests refuse to take any item with nbt data. You can click a virgin chest with such an item and it will set the filter, but it won't accept any items in. I guess that's because it drops the nbt data when setting the filter, so the filter won't match the actual item any more. For example if I try to insert a Meadows Drone in it, it sets the filter but won't take the item. Afterwards the filter will say just "Drone", so it registered the item type, but not the genome.
Factorization Barrels work fine with such items and will even accept multiple items if their nbt datas match exactly. You can store enchanted items, renamed items, power tools, bees, forestry saplings and even container items with stuff inside like Backbags or Canvas Bags. The only items they refuse to take are damaged tools but only if manually inserted. When the item comes from a pipe or tube, then even the damaged tools go in. And they retain their damage value, so another tool won't stack unless it has identical amount of damage.