It's easy if you're just measuring x amount of resources gathered, but there's no real way (as of this post) to identify that you've generated appropriate structures and contents via HQM.
Making HQM quests that identify that you've met particular resource gathering goals is pretty easy, but isn't a major aspect of the challenge. It'd be neat if there was a good fit for HQM in the challenge, but at this time at least, I can't see it.
While bored to death waiting for 1.7.10 FTB modpack releases, I tried downloading the "Modsauce" pack provided by ATLauncher. A lot of the mods in that pack work pretty well together, though I ended up removing a lot of mods (warfare based, mostly) that I personally didn't think fit my idea of a R2R challenge pack.
I think I could be pretty happy with a good set of 1.7.10 mods at this point, but I'm really torn on the "magic" side of it -- I've always tended to lean toward thaumcraft, and don't really want multiple magic mods in the pack. Something like Ars Magica/Blood Magic/Botania/Necromancy/Thaumcraft/Witchery would be a nightmare to deal with. Maybe one or two of those that don't insanely bog down a server? Blood Magic/Witchery seemed like they'd be more appropriate for pvp multiplayer servers, not so much a solo or small co-op R2R server.
AM2 was interesting and provided a good alternative to Thaumcraft, but I think both in the same pack may go a little overboard.
My unease with Thaumcraft has been and will always be with that blasted Taint. I know I can disable it in the config, but I feel that kind of detracts from what @
Azanor was going for with balance. I just hate taint that much. My OCD goes nuts when I see that stuff, and I waste ages trying to obliterate it and fix my "ruined" landscapes.
I may try loading in AM2 into my current pack setup and see how it plays with the other mods. If that doesn't work I'll switch back to Thaumcraft for the magic side of things. I'm itching to start the challenge with something beyond 1.6.4 mods, but I really want a good mix of potential adventure in there, not just the same stuff you see everywhere else.