Potentially, because there's less information for your game to sort through to get to the mods you do useSo this is probably a really dumb question, but...
Will my FPS improve if I just disable a bunch of mods that I don't/will never use? Even if the mods don't have any entites or blocks placed in the world?
Not entirely certain of the effect on your FPS, but it will definitely cause your game to launch faster