If by "hell of a lot harder to mass produce" you mean "actually impossible to mass produce" then yeah, very much so.
But at the same time, I put frames as "apiary related tools", and I put apiaries as "long before effective automation", but I suppose that role is now filled by Bee Houses, but that still means that (to me at least!) Frames are used prior to getting your automation set up. Yes, you need to get a squeezer and a carpenter built before you can craft apiaries, OR you can get 24 oak logs and find a apiarist villager and buy a apiary from him, so Apiaries can be obtained before you even have a bee to put in them.(unlike Bee Houses which need a honey comb to craft, meaning you have to use a scoop to gather hives until you have a comb. Yes, I know you can just BUY honey combs from villagers. I also know that that same Villager will sell you a Apiary is you have oak logs to trade for it, so the fact that you can buy a comb is irrelevant because the same NPC will sell you a fully built Apiary for a very reasonable price)
...Now I think I should look into how effective each of these frames are at killing bees. Chocolate is obvious(says on the wiki page it's 33% faster, right?), Necrotic is the one I'd be using most so getting some numbers on that would be important, and Oblivion Frames are dungeon loot, so they likely are pretty damn good at killing bees.
Naturally this will all be done with a single frame with a single basic queen each(all with the same lifespan, obviously), but I'll have to run the Oblivion Frame test on it's own because I will likely have to babysit the apiary to make sure that I always have a Oblivion Frame loaded.
With luck it'll be so effective that it'll murder bees fast enough that I won't need to babysit it because before I need to replace the frame I'll have practically outdone the Nazi Regime, except I'd be killing bees instead of people that weren't pure bred gerbils.