I briefly looked into them yesterday, they didn't seem horribly out of reach. There might be a piece I'm missing though.Brilliant, with the frames available from there you should be able to quickly cultivate new breeds without spending to much time. Hopefully you won't have to venture that far into thaumcraft to get them. If i remember correctly the metabolic frame increases the mutation chance and necrotic decreases the lifespan of the bees. Finally there was an oblivion fram that basically makes the lifespan one cycle but removes all products which i think was rather hard to get
I suspect the biggest piece of the puzzle is just churning out lots of magic wax. I kinda like this mechanic a bit because it gives us a use for ignoble bees: just set up a bunch of ignoble sorcerous/mystical/etc bees which do nothing but produce drones and combs for magic wax.