No, there is no death upon automation or anything if the sort.
There is a chance however if you try to push a bees production rate, or mutation chance too high, then it will become a "swarmer" princess.
These "swarmer" princesses will eventually die after a certain number of generations and not leave a Hier.
The only way to push this limit is to use either more than 2 mutators with uranium, over 8 I think? Soul frames, or more than 4 production boosting frames in alveary frame holders
This effectively nerfs "über breeders" and "über producers", by allowing the lowered use of abuse.
However, bear in mind that these swarmers can still have their species trait isolated out, so for very low chance species, putting high fertility and going for the 100% mutation rate to get it first time MAY be worth the risk.
ESP if you either get really lucky an it doesn't degrade, or you manage to produce enough drones that simply placing them in with a different princess for enough generations will convert it into a bee of that type, which can make more drones to isolate that trait. So über breeders have been nerferd in that it adds a lot of risk to doing things like this.
It has also nerfed the rate at bees with frame holders can produce, so no more 8 frames, fast, platinum comb every bee tick (27.5 seconds) production lines.
However, he drastically increased the life if swarmed princesses, so by having one alveary with several swarmers, and putting those swarmed bees into the über producers, there's no risk of the swarmer turning into a swarmer, as it already is one!
However, afaik there is no way to auto-harvest these swarmer hives, therefore no-one will use them, as they can't be 100% fully no interaction ever required will produce limitlessly forever automated. The same reason multitasks are so much hate being given. Not because they're expensive or cant be layered , but because fertilise is non- renewable, so needs to be mined again at some point, even if one vien lasts like. a month, if it could in theory run out , people dislike the concept.
Therefore I see 2 options.
1. Sengir adds a way to auto harvest swarmer hives
2. RichardG makes a turtle for it.
I heard there is an Apatite bee in some later versions of extra bees? Is this true? If so, ignore my comments about multifarms (which are apart from that, awesome btw)
After all, seems a bit rediculous that bees can make platinum, soul sand, oil, diamond and chicken nuggets, yet not fertiliser. Tell Binnie! (Or MysteriousAges!)