Uranium can be mined with an iron pick and is part of industrial craft 2 which recently got a massive overhaul, once uranium is mined you place it in a ic2 macerator, you might need a biohazard suit, scuba helmet rubber boots hazmat chest and legs (here's a hint type down in the bar down in the bottom of you Inventory screen and type this @industrial, no more then that and you have the whole of the ic2s items in your display, the chest and legs and helmet are orange and the boots are black, don't get them mixed up with static boots!) after that you need to place them in a ore washing plant, then a thermal centrifuge and then a canning machine, make sure you power these machines, (youtube a ic2 tutorial if you must) and then take the uranium fuel Rods and place them in a nuclear reactor, I would suggest looking at some designs for reactors, and plus nuclear power is very expensive to start and store, so I wouldn't suggest investing into it at a later stage when you have a lot of resources and you don't mind filling in a big hole! If you have anymore questions ask me or just search it up on youtube, I will definitely be making a tutorial for that soon!