Well, I'm done. At least until the next update. There's still plenty I could invent and automate, but I'm sticking a pin in that for now. When there's more quests I'll get back to it, but all the current ones are done.
Some of the more important lessons I've learned:
Get cobble gen going early, with with transfer nodes and world interaction upgrades. As many as you can throw at the problem. Don't be afraid to set a dedicated factory manager to compress the cobble. Octuple cobble is the best way to get bedrockium.
Drones rock for early automation. Also useful for automatically leveling your tinker's tools. A swarm of 4-6 with hammers will devastate a meteor field in no time flat.
A full sized salination plant will consume stupid amounts of water. Pumps are expensive. You can cut the number of pumps by having them run all night filling a bedrockium drum.
Mekanism stirling generators are the most efficient way to turn lava into power. Dead easy to automate too, using a tinker table as a bucket filler, and the import/output configurations.
Dungeons suck. They might be useful for some early dark steel or a handful of ender pearls, and a division sigil if you're lucky, but not especially worth it. Except...
One of the rooms that can be found in the dungeons has an enderman spawner. Place a smeltery under there, and you will have more ender pearls than you know what to do with.
Desch ore and Ilmenite ore both respond to fortune picks, but not often. Your subsequent desch, titanium shards, and iron shards can be doubled in an electric arc furnace, as wall as any raw meteoric iron from the moon or mars.
If you find yourself short on meteoric iron, it is somewhat abundant in the asteroids. Some asteroids have cores composed of BLOCKS of the stuff (the kind you craft from 9 ingots). Silicon is also common in the asteroids. Rather than hunting spire tips all the time, just do enough to get to the asteroids as quick as possible. Alternatively, it can be found in the deep dark. Either way, you've got to go to Mars first.