Keserian: Railcraft signaling, I've found, is something that tutorials are less than helpful with. It's better to just try it out yourself. That said, it hasn't changed much so all the tutorials are pretty valid. I know JeetTol on Youtube did one, that's very good.
I remember setting up in Unleashed, a Computer and ME bridge, connected to an enderchest. I was attempting to set it up so I could use the computer to request crafts from AE, by having it read the position and type of item in the enderchest. So I could move a piece of cobble into the enderpouch in a specific place, and have it craft a piston for example. Didn't work out so well, though that's my inability to program more than anything.
Ieldra: I've become annoyed by the necessity of using ender pearls and my own inability to farm them. (It's boring.) So I made a 'recipe' for the admin chunkloader, which uses a Nether Star, Four eyes of ender, and four pearls. (toss them out into NEI and cheat myself the loader.) That said, what I do is put two loaders down, one at each end of my train. (Loco plus 11 carts puts the ends out of reach of one on either end.)
I love interdimensional railways, but I find that trains break up going through portals. So I have the train run to an AE bridge. Basically an AE system consisting of a controller, two Quantum Rings and nothing but import and storage buses into the various loaders and unloaders. Completely silly, but much easier than fiddling around with coupler tracks.