I will argue the IC nuke thing. I built reactors in several games using known configurations. The last game I built one in, it had been running for quite awhile with no issues, and was a model I had used in the past several times with no problems. Suddenly for no reason it melted down and vaporized my beautiful base in to an ugly crater. Now, my bad I didn't use the reinforced blocks to encase it. I should have. But, I will never trust them again. That was pretty much the end of my long relationship with IC. Machines randomly "breaking" when you pick them up (what possible rationale was there for that?) I could live with. Random catastrophic meltdown was a deal breaker.
This sounds like a chunk unloaded and caused issues. It happens with every mod out there, some just have more explosive results than others.