I had an idea for a challenge pack called 'Uplift'. Basically, not only to you have to build your base and automate things, but you ALSO have to uplift the local species (i.e. villagers) by building them structures and machines to work on, teach them how to do so, and protect them from everything from bandit raids to monster invasions.
Then as you continue progressing, you can actually 'pass off' automation of certain goods to the locals as you spread civilization to other villages. Which includes building roads from village to village, setting up trade routes, making sure the trade routes are safe... kinda like FO4's settlement system, but without Preston Garvey pestering you every two or three minutes.
You also have options on how you interact with the villagers. In the end, you can either be a god-king EMPRAH or you can be known as a mysterious benevolent one, depending on how much 'hands on' or 'hands off' you are with respect to the villagers. The former goes by faster, but the latter is more passive and requires less activity on the player's part.
So something like AoE, with an invasion dynamic, and actually requiring you to create significant structures, including eventually a couple of megastructures (of course, by that time, you have the RFTools Builder access), and protect villagers while living near-ish to them. In other words, you also have to keep them from killing themselves on random stuff or all get turned into zombies. Without simply blocking them in, because they get upset when you do that.
So it isn't just automation for automation's sake, it's automation to further your goal of uplifting the local species into a space-faring people who revere/worship you.