Alchemy is as much a science as astrology or palm-reading - i.e. none. I do not play ThaumCraft because it is too unforgiving and destructive. Screw up in one tiny way, and (under default settings) a purple corruption spawns that ultimately eats half your map. Even under the easiest settings allowed by the config, you still end up spending hours clicking - randomly, more often than not - in GUIs to accomplish what can more easily and effectively be done in other mods. Also, I find that a lot of non-tech mods do not have an internal set of rules, but are more like "the laws of nature bend to what the plot demands". This results in extremely illogical and frustrating progression.