I have been on a skybase kick for a little while now. I generally build interconnected hexagon platforms up at whatever height feels right. The hexes generally get their own purpose like machines, gardens, bees, etc. As for where I build, I generally try to stay around spawn for the free semi chunkloading and ease of access, although I think next world will be desert based. My favorite vanilla builds have been in deserts and the TC4 silverwood biome changing mechanic thingimabob will allow me to build an actual oasis.