Breed every single possible bee, tree, and butterfly in your chosen modpack (get genes for each one, along with genes for all possible effects/tolerances/etc.) - without using gendustry.
Seriously? It's easily do-able, I'm almost there, except for the butterflies, which I've only collected a quantity of, but not bred them. There seems to be issue with the butterflies, it's never truly been completed to my knowledge, based on my web researching it all. For instance, there are references to "caterpillars" which haven't made it into the mod yet.
But yes, I have bred every bee manually, using the ExtraBees machines of course, I don't collect bees, I collect serum vials.
But never touched Gendustry.
Trees, same thing, I'm down to my last few species (kinda ran out of gas on the few which quite honestly are rather useless), what I did was I went into NEI and for every sapling, I looked at the recipe to see the cross-breed, then I compiled all that info into a spreadsheet so I didn't waste a lot of time or effort (edit to add: if you want to say I cheated, that's fair!). Additionally, I used the sieve blocks in the alvearies to collect tree pollen, I built a glass-enclosed area to house my trees, my butterflies, and there are four alvearies in there to collect pollen. I plant one tree species, let it run for an hour, and that gives me 12 pollen each run. Then I breed my tree species using the pollen on the leaf blocks, with a auto-spawner providing me with an endless stream of villagers who sell the proven grafters... etc etc
It can def be done, and I have the Monster SSP world to prove it (not uploaded anywhere tho for proof haha). You've now motivated me to go figure out all the butterfly species now, so thanks.