Great thread, I hope people will share their best "tips and tricks" for skyblock.
Since I don't know this "Ex Nihilo" mod at all, I've struggled a bit to get going, so I'll share the two tips that really helped me. I think one of them is in the in-game Guide book (which is found by pressing the E key and clicking on one of the book icons), but the other tip I didn't find anywhere until my server-mate told me.
Tip#1 - to make Tinkers Construct Smeltery, you need clay which you get from making Oak Barrels and waiting for rain, then when the barrel is 100% full you right click with a Dust to instantly get a clay block. From this, you can make Tinkers Grout.
Tip#2 - after you make the Smeltery, you still need lava somehow and I was lost until someone informed me that you can make an Ex Nihilio Crucible, smelt it, then place it over some sort of flame (torches, or better yet, put it right over your one lava block in your cobblegen setup for 2x speed), and finally, right click the crucible with cobblestone. Eventually you will get lava which you can bucket over to the Smeltery, and now you're up and running!
My first two days were spent making more dirt (saplings into Oak Barrel) so my tree farm is now 20 trees, and all the basic Tinkers Construct stuff. By sifting, I was able to get enough stuff to make the Thermionic Fabricator, and then an Assembly Table with 1 Laser, all powered via a single Survival Generator... which then allowed me to make the IC2 Metal Former and IC2 Generator... which then allowed me to make steel shafts for constructing Immersive Engineering Water Wheels to begin generating RF/t. That's where my Day#2 ended, because I got fed up and frustrated with placing all the water blocks. The power source is so good for early game, I just gotta deal with the aggravation.
Speaking of Immersive water wheels,
does this image still show the optimal water block configuration for Infinity Evolved Expert? It's pretty messy. I might sacrifice some power and skip some of those water blocks.
EDIT: I made a creative world, and with the use of the Thermal Expansion Multimeter I confirmed that water wheel setup will generate 88 RF/t by using all of the indicated waterblock locations. 68 RF/t comes from the very top waterblocks, with the other 3 locations providing the rest of the power. So I'd lose 20 RF/t by not placing those waterblocks, and that would be inefficient.... so messy, it is, then!