If you happen to get a Lengthening Catalyst (instead of a Power as madnewmy got), you can go the Regen route with just 2 ghast tears also. That's what I used to make it up to a Tier 4 Orb, combined with a full set of Self-Sacrifice runes I believe, (my early failed attempts at getting out of the tier 2 stage are recorded somewhere on Padfoote's thread). It also helps out when your filling the 3/4ths of a million LP needed for a full suit of Blood Armor (24 filled sockets), as I just did that again recently for a friend, and even afking with a Ritual of the Feathered Knife/Regen combo I needed the Regen II effect I brewed into a flask to make it in a reasonable amount of time.For my tier 3 orb, I made a Instant Health IV potion from blood magic, you just need to find power catalyst in a chest (In my case, I got it from a reward bag in AgS)
You will probably need Tinker's canister since it heals you 16.5 hearts.
Made it wayyyyyyy easier