If Biomes O'Plenty will get introduced then starting new world would be the best option, it will screw up biome generation on borders of chunks and mess up with bees (Forestry apiaries and farms check when loading world what biome should be during world gen in a given place, not what biome it really is). Natura and TConstruct probably will be in packs, Natura changes worldgen quite a bit (bushes, new trees, clouds and nether, recently a lot) and Nether without it is just boring. TConstruct has very good early game progression, so I'd recommend starting new world to get to know this mod better. You can always just move most important buildings using development versions of MCEdit