Usually after I can make the runes for it I go for the Gourmaryllis, and before then the endoflame. For this playthrough, I'm considering maybe making a mass-endoflame area semi-automated, or maybe trying out something like that entropinnyum/AE automated system, except with Refined Storage instead of AE.
Anyways, what's your go-to?
Anyways, what's your go-to?