I always use silk touch. If you want to use fortune, it's easy to setup a few autonomous activators and apply fortune to your ores afterwords.
this. Altho quite honestly, i'm not really even sure you need to run silk touch either. All i run is the top-tier speed upgrade on my Ender Quarry. My argument is that, sure, silk touch can give me more raw materials with some ore processing... but if I really need all that extra stuff, then I'll just run my quarry some more.
During very early game (when silk touch is a luxury I usually don't have), my biggest need for silk touch is to mine the redstone ore blocks... because TE pulverzing redstone ore blocks gives TE Cinnabar, and TE Cinnabar can then be used with Ferrous Ore in a TE Induction Smelter to give a 100% guaranteed Shiny Ingot for every Ferrous Ore block processed. Shiny is essential to make Enderium ingots, so I can make Tesseracts and really up my game (i.e. get out of early game).
But once I've got an Ender Quarry going (which means I've already got my Tesseracts), and I'm no longer in early game, I find I don't really have a big need to silk touch everything. But, I haven't done the math to see which is more energy efficient - silk touching/processing, or just running the quarry for a longer time. Mainly because I really don't care which is more energy efficient, they both would give more than enough materials.
