Unless of course you're busily building along the edge and aren't watching your power consumption...
That's why I always keep a pair of longfall boots equipped when building in the sky, or nanosuit boots and, their quantum equivalents.
I like to build my bases inside of landmarks, such as giant mountains. It gives them a more natural, disguised look when viewed from the outside. It can even discourage griefing during server play. You can hide quite a bit in those mountains.
Autocrafting:
http://i.imgur.com/JCnP473.jpg
Everything is spaced out on a grid, with plenty of room left for Greg's large multiblock structures and, the pipes often required to automate them. If you're an organized person you can do what I did and, label your gridded chart with each machine's purpose.
Ore processing:
http://i.imgur.com/Y9z9uYB.png
I decided to compartmentalize everything that runs continuously such as ore grinding food cooking and, rubber production from resign.
There's plenty of space:
http://i.imgur.com/46HyR9n.png
This is just one of ten floors not including the basement. Auto-processing with Gregtech installed can get quite large.
Power generation, storage, processing and, my personal room all live on a different floor. Working within the mountain's irregular shape has been pretty fun thus far, give it a shot. If you're a better builder you can make a rather pretty factory.