Game volume not really a issue maybe boost the whole volume or something when encoding if it gives you that options, or just voice if you can do that. I don't really mind hearing mouse and keyboard clicks if that is what you are referring to if it means hearing voice better. I had exact issue before and I would just try to match up the sound settings to other youtubers, by listening to them then going over to my vid listening. I don't think you want to force people to crank up their volumes to hear then they go over to someone else and it's insane loud or vice versa, that is my 2 cents anyway.