I tend to go min/max with ME systems. The smaller drives are far better for usual misc stuff you find while exploring and/or crafting. 1K drives never quite seem to be enough so I tend to stick with 4K for most of my drive. Once I get the resources built up though, then I start looking at the larger drives... for specific thinks like iron ingots, copper ingots, gems, thaumcraft crystals etc... And I limit them to only allow 1 or two different items on a single drive. For the rest, I simply build myself more 4K drives. This way I can still get good storage for the items I have a larger amount of in my system while making the most efficient use of each drive.
My reasoning for this; the larger the drive, the more drive memory it takes to store a new type of item, compaired to how much less it takes to just store more of an item already on the drive. 4K have about the best compromise between total storage space, and low memory cost of adding a new item to the storage. While the larger drives are best used for holding items that you have a very large amount of.