Having seen your other post, the first thing to turn off is anything that uses magic like blood magic, botania, and psi. The next thing to shut off is any mods you (probably) do not know and will likely not learn. These mods tend to be things like xnet, tesla, and pneumaticraft. They key here is to do some research and find out what mods do exactly what. If you are a huge fan of enderio, you MIGHT not need extra utils. Be very careful to not delete any core such as brandon's core, without knowing what mod they belong to. In this case, if you delete brandon's core, draconic evolution will not work.
The other way to come about this is to start with a mod like Vanilla+ and add in the things you love, (for example) tinker's construct and enderio.