The basics didn't change that much from previous versions. I can give you some basic hints:
- You'll need Certus Quartz (go mine it). You'll need it in it's broken down form (Certus Quartz Crystals), the dust (Certus Quartz Dust) and the charged version (Charged Certus Quartz Crystal).
- You can find charged Certus Quartz (but it's rare) or you can charge it in a machine. Thermal Expansion has the Energetic Infuser that can do that job.
- You'll need Fluix Crystals. You create them by throwing Charged Certus Quartz, Redstone & Nether Quartz in a pool of water.
- You'll need to power your ME system: Connect some kind of power cable to an Energy Acceptor
- You'll need presses, which you can find inside of meteors
For your first ME system:
- Craft the Energy Acceptor, place it somewhere and connect power to it
- Craft an ME Controller and place it next to the Energy Acceptor (if it starts glowing in all sorts of colors, it has power)
- Craft an ME Drive and place it next to the ME Controller
- Craft a Storage Cell and place it inside the ME Drive (you'll need to craft an Inscriber and use the presses to craft the processors)
- Craft an ME Glass Cable and place it above the drive (or the Controller)
- Craft an ME Terminal and place it on the Cable.
Voilà, you have a basic ME system.
There's much much more to AE2 than just what I described above. Auto crafting is one of the things I try to get going as soon as possible after I have my Drive with a few storage cells.
Then there's liquid storage (which I love), the whole bus system (with P2P tunnels) and quite a few things more.
You'll need to learn bit by bit about AE2 and what it can do. The wiki helps, too:
http://ae-mod.info/
Good luck.