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You could make a test instance and remove Mine and Modtweaker and heavy mods that add many items (Binnie's) and see if it reduces the lag. Come back with reports :)
1.2.2 is way more stable than 1.2.0. 1.2.3 will soon be made, I am just very busy recently. And updating Mekanism is a suggestion. Not sure if it fixes it, you tell me : P