Now, this is slightly off-topic but can help quite a bit if you experience a lot of stuttering or lag:
One big thing is being smart when building pipe/tube systems. Pipes (barring logistics pipes which I know pretty much nothing about) are generally the worse option prestandawise, partly because overflows are solved with sucking up stuff instead of by not sending more stuff and partly because if it's incorrectly built there can be massive overflow quite easily. The second issue can be overcome through smart building but the first is harder, and I don't know that much about piping so I can't tell you much more than that.
Tubes are generally better IMO, in that they send whole stacks, they stop sending if there's no correct inventory, and they have a logic that to my mind is easier to build smart around, stacks going to closest inventory rather than going randomly. Building those in a smart way generally comes down to two main things: Use buffers when possible, and avoid long-distance tubing if possible.
- What buffers do is they stack up input in an inventory, and after some time they send it along again. If you have macerators hooked up that output like 3 items per second, and sending them 80 meters away in pneumatic tubes, you'll have a thick steady stream of hundreds of entities going around your system. If you throw on a buffer, they'll collect those and send groups of 15 items every five seconds. You have to wait a liittle longer to get your stuff, but it reduces the amount of tube cluttering by 80%.
- Avoiding long-distance tubing can be done several ways. It's not the distance that's relevant actually, it's the amount of seconds the entities spend in the system. Using magtubes severely reduces this, but what is even better is having a bunch of ender chests (though it doesn't look as awesome). You can also try to build your factories in a compact way - while 20 meters isn't a long distance, if every segment always has 10+ items in them, halving that distance does quite a bit for the stuttering.
Sorry for the slight derail but hope it was useful.