I have found out that mutators are not really needed for most mutations.
For now, all my mutations had 8+ % chance, and I ramped them up to above 100% with 7 soul frames.
Add 6 chocolate frames to make the bees die in the next "bee tick", and you will have a setup that can mutate multiple bees at very low cost, compared to mutators.
What I mean by that is that you could theoretically have 11 soul frames and 6 chocolate frames, for a boost of 86 times the original chance, and still do it very fast.
Or you could trade 1 chocolate frame for an additional soul frame and get a boost of 129 times.
That means that even the 1% mutations would be assured, for only a portion of durability on what is basically seeds, wood, string, soul sand and cocoa beans. All of that being very easily gotten and renewed (soul sand needs MFR sludge boiler), it makes mutating the bees really easy as soon as you get an alviary.
Added bonus is that it lets you use your precious green stuff for generating the power you will need for the rest of your base.