You could do what I used to do. Have a tesseract that the interfaces connect to, then pipe them out at the other side. Then you can put the machines in a dedicated room without having to have long lines of ME cable. Just need to route the materials when they get on the other side. Many mods can handle this without issue (BC, TE, or LP come to mind).
Another thing I did was have a bank of machines (30-60 pulverizers with 2x as many redstone furnaces) with Factorization Routers to push and pull items from the banks. Made things much simpler on the eyes and more space conscious.