You absolutely can. I have a design for a 1x2(+1)x2 that's horizontally tileable. (The +1 is for the chest output.)
I'll get you a screenshot when I can.
EDIT: Screenshots attached. Pay attention to the markings on the pipes; you get those by right-clicking the pipes with a stick or an Omniwrench. The markings mean that the pipe is in one-way mode from that direction; it prevents horizontal cross connections. Additionally, I use two DSUs and a barrel (DSUs don't take drones), but you can use chests, too. Or any other container.